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Nature Research, Nature Genetics, 3(46), p. 214-215, 2014

DOI: 10.1038/ng.2904

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Intratumoral heterogeneity in kidney cancer

Journal article published in 2014 by Christopher J. Ricketts, W. Marston Linehan
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.