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Karger Publishers, Case Reports in Neurology, 1(3), p. 91-96

DOI: 10.1159/000327554

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Systemic Thrombolytic Therapy Alone and in Combination with Mechanical Revascularization in Acute Ischemic Stroke in Two Children

Journal article published in 2011 by B. Modrau ORCID, L. Sørensen, N. J. Bartholdy, P. von Weitzel-Mudersbach, Grethe Andersen ORCID, P. V. Rasmussen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Thrombolytic therapy is not recommended for acute ischemic stroke (AIS) in patients under the age of 18 and published experience is limited. In this case report, we describe two children treated with systemic thrombolytic therapy. One child received additional mechanical revascularization and achieved a good clinical outcome. The differences in the fibrinolytic system and the different etiology of AIS in childhood may limit a simple extrapolation of the adult guidelines for systemic thrombolytic therapy. Acute multimodal imaging to clarify the etiology of AIS might help to select the most appropriate treatment modality.