Published in
Public Library of Science, PLoS ONE, 3(6), p. e17673, 2011
DOI: 10.1371/journal.pone.0017673
Links
- ORCID
- ORCID
- Public Library of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [citeseerx.ist.psu.edu] | PDF
Tools
Role of T198 Modification in the Regulation of p27Kip1 Protein Stability and Function
,
Francesca Lovat,
Linda Fabris,
Alfonso Colombatti,
Barbara Belletti ,
Gustavo Baldassarre
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Abstract
The tumor suppressor gene p27Kip1 plays a fundamental role in human cancer progression. Its expression and/or functions are altered in almost all the different tumor histotype analyzed so far. Recently, it has been demonstrated that the tumor suppression function of p27 resides not only in the ability to inhibit Cyclins/CDKs complexes through its N-terminal domain but also in the capacity to modulate cell motility through its C-terminal portion. Particular interest has been raised by the last amino-acid, (Threonine 198) in the regulation of both protein stability and cell motility.