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Public Library of Science, PLoS ONE, 5(8), p. e64696, 2013

DOI: 10.1371/journal.pone.0064696

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Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome

Journal article published in 2013 by Miguel Silva-Ramos ORCID, Paulo Correia de-Sá, Isabel Silva, Olga Oliveira, Sónia Ferreira, Maria Júlia Reis, José Carlos Oliveira, Paulo Correia-De-Sá ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background Nowadays, there is a considerable bulk of evidence showing that ATP has a prominent role in the regulation of human urinary bladder function and in the pathophysiology of detrusor overactivity. ATP mediates nonadrenergic-noncholinergic detrusor contractions in overactive bladders. In vitro studies have demonstrated that uroepithelial cells and cholinergic nerves from overactive human bladder samples (OAB) release more ATP than controls. Here, we compared the urinary ATP concentration in samples collected non-invasively from OAB women with detrusor overactivity and age-matched controls. Methods Patients with neurologic diseases, history of malignancy, urinary tract infections or renal impairment (creatinine clearance