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Oxford University Press, Metallomics, 7(6), p. 1216-1219, 2014

DOI: 10.1039/c4mt00060a

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Decreased Serum Zinc Is An Effect Of Ageing And Not Alzheimer's Disease

Journal article published in 2014 by Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph N. Martins ORCID, David Ames, Colin L. Masters, Ashley I. Bush ORCID, Blaine R. Roberts
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer’s disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.