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Published in

Hindawi, Journal of Probability and Statistics, (2012), p. 1-37

DOI: 10.1155/2012/931416

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Secondary Analysis under Cohort Sampling Designs Using Conditional Likelihood

Journal article published in 2012 by Olli Saarela, Sangita Kulathinal, Juha Karvanen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Under cohort sampling designs, additional covariate data are collected on cases of a specific type and a randomly selected subset of noncases, primarily for the purpose of studying associations with a time-to-event response of interest. With such data available, an interest may arise to reuse them for studying associations between the additional covariate data and a secondary non-time-to-event response variable, usually collected for the whole study cohort at the outset of the study. Following earlier literature, we refer to such a situation as secondary analysis. We outline a general conditional likelihood approach for secondary analysis under cohort sampling designs and discuss the specific situations of case-cohort and nested case-control designs. We also review alternative methods based on full likelihood and inverse probability weighting. We compare the alternative methods for secondary analysis in two simulated settings and apply them in a real-data example.