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Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.

Journal article published in 2004 by Jan Rehwinkel ORCID, Andrea Herold, Kerstin Gari, Thomas Köcher, Michaela Rode, Fl Ciccarelli, Matthias Wilm, Elisa Izaurralde
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

In yeast cells, the THO complex has been implicated in mitotic recombination, transcription elongation and mRNA nuclear export. The stable core of THO consists of Tho2p, Hpr1p, Mft1p and Thp2p. Whether a complex with similar functions assembles in metazoa has not yet been established. Here we report that Drosophila melanogaster THO consists of THO2, HPR1 and three proteins, THOC5-THOC7, which have no orthologs in budding yeast. Gene expression profiling in cells depleted of THO components revealed that