Published in

American Urological Association (AUA), The Journal of Urology, 5(184), p. 1895-1900, 2010

DOI: 10.1016/j.juro.2010.06.106

Links

Tools

Export citation

Search in Google Scholar

Association of Tumor Necrosis With Pathological Features and Clinical Outcome in 754 Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: An International Validation Study

Journal article published in 2010 by Christian Seitz, Amit Gupta, Shariat Sf, Shahrokh F. Shariat, Kazumasa Matsumoto, Wassim Kassouf, Thomas J. Walton, Walton Tj, Hans-Martin Fritsche, Fritsche Hm, Wolfgang Otto ORCID, Stefan Tritschler, Patrick J. Bastian, Bastian Pj, Joaquin Carballido and other authors.
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

Full text: Unavailable

Red circle
Preprint: archiving forbidden
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

PURPOSE: Tumor necrosis is associated with a poor oncological outcome in patients with upper tract urothelial carcinoma and other malignancies. We validated the association of tumor necrosis with pathological features and clinical outcomes in a large international cohort of patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. MATERIAL AND METHODS: This retrospective study included 754 patients treated with radical nephroureterectomy at a total of 9 centers. Tumor necrosis was scored as greater than 10% of tumor area based on microscopic evaluation. RESULTS: Tumor necrosis was present in 165 specimens (21.9%). The prevalence of tumor necrosis increased with advancing pathological stage, including 7%, 10.6% and 50% for T1, T2 and T3-4, respectively (p