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Elsevier, International Journal of Cardiology, 3(152), p. 337-344, 2011

DOI: 10.1016/j.ijcard.2010.08.001

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Imbalance between pro-angiogenic and anti-angiogenic factors in rheumatic and mixomatous mitral valves

Journal article published in 2011 by Giovanni Mariscalco, Bruno Vd, Roberto Lorusso, Fausto Sessa, Vito Domenico Bruno ORCID, Gabriele Piffaretti, Maciej Banach, Paolo Cattaneo, Giuseppe Paolo Cozzi, Cozzi Gp, Andrea Sala
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Background: A balance between angiogenic and anti-angiogenic factors is critical in tissue development, tissue repair and homeostasis. Aberrant angiogenesis has been implicated in several pathologic conditions, including valvular heart disease. The aim of this study was to ascertain the pathogenetic role of angiogenesis in rheumatic and mixomatous mitral valve diseases. Methods: Leaflets from mixomatous (n=20) and rheumatic (n=20) mitral valves removed from surgical patients, and normal mitral valve (n=6) obtained at autopsy were collected. Immunohistochemical studies were performed on sequential valve sections, evaluating CD31, CD34, alpha smooth muscle actin (alpha-SMA), vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGFR1), VEGF receptor-2 (VEGFR-2), and chondromodulin-I (Chm-I). Results: Immunohistochemistry revealed significant differences among groups in CD31 (p=0.001), CD34 (p