Springer Nature [academic journals on nature.com], Modern Pathology, 9(24), p. 1237-1247, 2011
DOI: 10.1038/modpathol.2011.74
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Only a minority of patients who undergo surgical resection for pancreatic ductal adenocarcinoma are cured. Since patient outcome is not reliably predicted using pathological factors (tumor stage, differentiation, resection margin status) alone, markers of tumor behavior are needed. One candidate predictor of pancreatic cancer outcome is e-cadherin status. CDH1 is a tumor suppressor gene encoding an important cell adhesion molecule (e-cadherin). The aim of this study was to determine if, among patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, loss of e-cadherin expression was an independent predictor of poor outcome.