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Springer Nature [academic journals on nature.com], Modern Pathology, 9(24), p. 1237-1247, 2011

DOI: 10.1038/modpathol.2011.74

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Loss of E-Cadherin Expression and Outcome among Patients with Resectable Pancreatic Adenocarcinomas

Journal article published in 2011 by Seung-Mo Hong ORCID, Ang Li, Kelly Olino, Christopher L. Wolfgang, Joseph M. Herman, Richard D. Schulick, Christine Iacobuzio-Donahue, Ralph H. Hruban, Michael Goggins
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Only a minority of patients who undergo surgical resection for pancreatic ductal adenocarcinoma are cured. Since patient outcome is not reliably predicted using pathological factors (tumor stage, differentiation, resection margin status) alone, markers of tumor behavior are needed. One candidate predictor of pancreatic cancer outcome is e-cadherin status. CDH1 is a tumor suppressor gene encoding an important cell adhesion molecule (e-cadherin). The aim of this study was to determine if, among patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, loss of e-cadherin expression was an independent predictor of poor outcome.