Published in

Open Access Publishing London, Head and Neck Oncology, 1(3), 2011

DOI: 10.1186/1758-3284-3-32

Elsevier, Year Book of Pathology and Laboratory Medicine, (2012), p. 198-201

DOI: 10.1016/j.ypat.2011.11.033

Links

Tools

Export citation

Search in Google Scholar

Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome

Journal article published in 2011 by Anna Likhacheva, David I. Rosenthal, Ehab Hanna ORCID, M. S. Said, Michael Kupferman, Franco DeMonte, Adel K. El-Naggar
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Abstract Background The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown. Methods We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC. Results The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management. Conclusion Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.