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National Academy of Sciences, Proceedings of the National Academy of Sciences, 15(98), p. 8388-8394, 2001

DOI: 10.1073/pnas.111006398

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Homologous DNA recombination in vertebrate cells

Journal article published in 2001 by Eiichiro Sonoda, Yamashita Ym, Minoru Takata ORCID, Yukiko M. Yamashita, Ciaran Morrison, Shunichi Takeda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.