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Taylor and Francis Group, Leukemia & Lymphoma, 5(51), p. 822-838

DOI: 10.3109/10428191003646002

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Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

Journal article published in 2010 by Nadiia Bilous, Riccardo Bomben, Michele Dal Bo, Michele Dal Bo, Daniela Capello, Francesco Forconi, Luca Laurenti, Francesco Bertoni, Dimitar G. Efremov, Roberto Marasca ORCID, Giovanni Del Poeta, Zoya Martina, Iryna Kryachouk, Iryna Dyagil, Gianluca Gaidano and other authors.
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Abstract

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.