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Elsevier, Bioorganic Chemistry, (40), p. 108-113, 2012

DOI: 10.1016/j.bioorg.2011.09.006

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A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines

Journal article published in 2012 by Gert Schwach, Patchanita Thamyongkit, Lorenz Michael Reith, Bernhard Svejda, Günther Knör, Roswitha Pfragner, Wolfgang Schoefberger ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this study, a completely water soluble tri-cationic porphyrin-EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl(4) in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines.