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Public Library of Science, PLoS ONE, 5(7), p. e36910, 2012

DOI: 10.1371/journal.pone.0036910

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Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study.

Journal article published in 2012 by van Woudenbergh Gj, Geertruida J. van Woudenbergh, Daphne L. van der A., Dora Romaguera, Chirlaque Md, Eomois Pp, Matthias B. Schulze, Franks Pw, Kim Overvad, Nicholas J. Wareham, Peter Nilsson, Giovanna Masala, Amalia Mattiello, Annemieke M. W. Spijkerman, Olov Rolandsson and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. METHODOLOGY/PRINCIPAL FINDINGS The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-