Dissemin is shutting down on January 1st, 2025

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Wiley, British Journal of Pharmacology, 1(154), p. 174-182, 2008

DOI: 10.1038/bjp.2008.80

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Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT1Areceptors

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background and purpose: 5-HT (serotonin) is known to be involved in neuroinflammation and immunoregulation. The human immunodeficiency virus (HIV) targets cells such as monocytes/macrophages, which colocalize with 5-HT-releasing cell types, mostly platelets. In this study, we investigated the effects of 5-HT on HIV-1-infected macrophages in vitro.