Published in
Wiley, British Journal of Pharmacology, 1(154), p. 174-182, 2008
DOI: 10.1038/bjp.2008.80
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT1Areceptors
Journal article published in 2008 by
B. Manéglier,
G. J. Guillemin 
,
P. Clayette,
C. Rogez-Kreuz,
B. J. Brew,
D. Dormont,
C. Advenier,
P. Therond,
O. Spreux-Varoquaux
,
P. Clayette,
C. Rogez-Kreuz,
B. J. Brew,
D. Dormont,
C. Advenier,
P. Therond,
O. Spreux-Varoquaux
This paper is made freely available by the publisher.
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Abstract
Background and purpose: 5-HT (serotonin) is known to be involved in neuroinflammation and immunoregulation. The human immunodeficiency virus (HIV) targets cells such as monocytes/macrophages, which colocalize with 5-HT-releasing cell types, mostly platelets. In this study, we investigated the effects of 5-HT on HIV-1-infected macrophages in vitro.