Links
- ORCID
- Crossref | PDF
- [infoscience.epfl.ch] | PDF
- [infoscience.epfl.ch] | PDF
- [www.zora.uzh.ch] | PDF
- [doc.rero.ch] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.
Journal article published in 2012 by
Sylvie Rockel,
Marcel Geertz,
Korneel Hens,
Bart Deplancke 
,
Sj J. Maerkl
,
Sj J. Maerkl
Abstract
Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.