Published in
American Society of Hematology, Blood, 26(125), p. 4069-4077, 2015
DOI: 10.1182/blood-2014-11-611905
Links
- American Society of Hematology | PDF
- ORCID
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization
Journal article published in 2015 by
Viola Lorenz,
David Stegner,
Simon Stritt,
Timo Vogtle 
,
Friedemann Kiefer,
Walter Witke,
Jürgen Schymeinsky,
Steve P. Watson,
Barbara Walzog,
Bernhard Nieswandt
,
Friedemann Kiefer,
Walter Witke,
Jürgen Schymeinsky,
Steve P. Watson,
Barbara Walzog,
Bernhard Nieswandt
This paper is made freely available by the publisher.
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Abstract
Key Points CLEC-2 can be downregulated from circulating platelets by anti–CLEC-2 antibodies through Src-family kinase-dependent internalization. Platelet-specific Syk deficiency abrogates anti–CLEC-2 antibodies-induced thrombocytopenia, but not CLEC-2 internalization.