Published in
American Society of Hematology, Blood, 26(125), p. 4032-4041, 2015
DOI: 10.1182/blood-2014-11-610329
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The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model
Journal article published in 2015 by
Matthew D. Blunt,
Matthew J. Carter,
Marta Larrayoz 
,
Lindsay D. Smith,
Maria Aguilar-Hernandez,
Kerry L. Cox,
Thomas Tipton,
Mark Reynolds,
Sarah Murphy,
Elizabeth Lemm,
Samantha Dias,
Andrew Duncombe,
Jonathan C. Strefford,
Peter W. M. Johnson,
Francesco Forconi
and other authors.
,
Lindsay D. Smith,
Maria Aguilar-Hernandez,
Kerry L. Cox,
Thomas Tipton,
Mark Reynolds,
Sarah Murphy,
Elizabeth Lemm,
Samantha Dias,
Andrew Duncombe,
Jonathan C. Strefford,
Peter W. M. Johnson,
Francesco Forconi
and other authors.
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Abstract
Key Points PF-04691502 induces potent apoptosis in CLL cells and suppresses prosurvival anti–immunoglobulin M signaling and CXCL12-induced migration. PF-04691502 displays powerful antitumor effects in vivo in the Eμ-TCL1 mouse model.