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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(59), p. 7842-7846, 2015

DOI: 10.1128/aac.02019-15

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In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli

Journal article published in 2015 by Shawn Vasoo, Scott A. Cunningham ORCID, Nicolynn C. Cole, Peggy C. Kohner, Sanjay R. Menon, Kevin M. Krause, Kelly A. Harris, Partha P. De, Tse Hsien Koh, Robin Patel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively.