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Rates of Acquisition of Pneumococcal Colonization and Transmission Probabilities, by Serotype, Among Newborn Infants in Kilifi District, Kenya
Journal article published in 2012 by
Caroline Cc Tigoi,
Hellen Gatakaa,
Angela Karani,
Daisy Mugo,
Stella Kungu,
Eva Wanjiru,
Jane Jomo,
Robert Musyimi,
John Ojal,
Nina E. Glass 
,
Osman Abdullahi,
J. Anthony G. Scott,
Ja Anthony G. Scott
,
Osman Abdullahi,
J. Anthony G. Scott,
Ja Anthony G. Scott
Abstract
BACKGROUND: Herd protection and serotype replacement disease following introduction of pneumococcal conjugate vaccine (PCV) are attributable to the vaccine's impact on colonization. Prior to vaccine introduction in Kenya, we did an epidemiological study to estimate the rate of pneumococcal acquisition, by serotype, in an uncolonized population. METHODS: Nasopharyngeal swab specimens were taken from newborns aged ≤ 7 days and weekly thereafter for 13 weeks. Parents, and siblings aged