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Hindawi, Hepatitis Research and Treatment, (2011), p. 1-9, 2011

DOI: 10.1155/2011/697162

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Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand.

Journal article published in 2011 by Olivier Galy, Isabelle Chemin, Emilie Le Roux, Emilie Le Roux, Stéphanie Villar, Florence Le Calvez-Kelm, Florence Le Calvez-Kelm ORCID, Myriam Lereau, Doriane Gouas, Beatriz Vieco, Iris Suarez, Maria-Cristina Navas, Michèle Chevallier, Helene Norder, Petcharin Srivatanakul and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.