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BMJ Publishing Group, Annals of the Rheumatic Diseases, 3(64), p. 347-354, 2004

DOI: 10.1136/ard.2004.025676

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Primary Sjögren's syndrome: new clinical and therapeutic concepts

Journal article published in 2004 by A. Tzioufas, Tzioufas Ag, M. Ramos-Casals ORCID, J. Font
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This paper is available in a repository.

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Abstract

Sicca features are the central clinical manifestations of Sjögren's syndrome (SS), but recent studies have confirmed that primary SS has a systemic expression, including extraglandular manifestations. Patients with a predominantly extraepithelial expression should be managed differently from patients with predominantly periepithelial or sicca limited disease. In coming years treatment will be based on muscarinic agonists for sicca features and immunosuppressive/biological agents for extraglandular features.