Published in
EMBO Press, EMBO Reports, 12(14), p. 1143-1148, 2013
Links
- ORCID
- ORCID
- ORCID
- EMBO Press | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells
Journal article published in 2013 by
Rémi Peyronnet 
,
Joana R. Martins,
Fabrice Duprat,
Sophie Demolombe,
Malika Arhatte,
Martine Jodar,
Michel Tauc ,
Christophe Duranton,
Marc Paulais,
Jacques Teulon,
Honoré Eric,
Amanda Patel
,
Joana R. Martins,
Fabrice Duprat,
Sophie Demolombe,
Malika Arhatte,
Martine Jodar,
Michel Tauc ,
Christophe Duranton,
Marc Paulais,
Jacques Teulon,
Honoré Eric,
Amanda Patel
This paper is made freely available by the publisher.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
This study provides evidence that the activity of renal non-selective stretch-activated ion channels (SACs) depends on Piezo1 but is negatively regulated by Polycystin-2 (PC2). PC2 co-immunoprecipitates with Piezo1 and deletion of its N-terminal domain prevents both this interaction and inhibition of SAC activity.