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Public Library of Science, PLoS ONE, 4(3), p. e1962, 2008

DOI: 10.1371/journal.pone.0001962

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Onset Dynamics of Action Potentials in Rat Neocortical Neurons and Identified Snail Neurons: Quantification of the Difference

Journal article published in 2008 by Maxim Volgushev, Aleksey Malyshev, Pavel Balaban, Marina Chistiakova, Stanislav Volgushev, Fred Wolf ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The generation of action potentials (APs) is a key process in the operation of nerve cells and the communication between neurons. Action potentials in mammalian central neurons are characterized by an exceptionally fast onset dynamics, which differs from the typically slow and gradual onset dynamics seen in identified snail neurons. Here we describe a novel method of analysis which provides a quantitative measure of the onset dynamics of action potentials. This method captures the difference between the fast, step-like onset of APs in rat neocortical neurons and the gradual, exponential-like AP onset in identified snail neurons. The quantitative measure of the AP onset dynamics, provided by the method, allows us to perform quantitative analyses of factors influencing the dynamics.