Interplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy

Murtaza, Iram; Wang, Hong-Xia; Mushtaq, Sobia; Javed, Qamar; Li, Pei-Feng

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Interplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy

Journal article published in 2013 by Iram Murtaza, Hong-Xia Wang, Sobia Mushtaq, Qamar Javed, Pei-Feng Li

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Abstract

Objective(s): The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy.