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Advances in Glucocorticoid-Induced Osteoporosis

Journal article published in 2011 by Debby den Uyl, Irene E. M. Bultink ORCID, Willem F. Lems
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures. Recently, many published studies have focused on the cellular and molecular mechanisms of bone metabolism, the pathophysiology of GIOP, and the intervention options to prevent GIOP. In this review, recent advances in GIOP are summarized, particularly recent progress in our understanding of the mechanisms of GIOP resulting in improved insight that might result in the development of new treatment options in the near future.