Links
- ORCID
- ORCID
- Crossref | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [link.springer.com] | PDF
Tools
Cytogenetic and Molecular Predictors of Outcome in Acute Lymphocytic Leukemia: Recent Developments
Journal article published in 2012 by
Ilaria Iacobucci,
Cristina Papayannidis 
,
Annalisa Lonetti,
Anna Ferrari ,
Michele Baccarani,
Giovanni Martinelli
,
Annalisa Lonetti,
Anna Ferrari ,
Michele Baccarani,
Giovanni Martinelli
Abstract
During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T- acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.