<b><i>Background:</i></b> Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma. <b><i>Objective:</i></b> To investigate the occurrence of <i>BRAF</i> and <i>cKIT</i> impairments in patients with sinonasal melanoma in Southern Italy. <b><i>Methods:</i></b> Eleven sinonasal melanomas were screened for <i>BRAF</i> mutations and <i>cKIT</i> alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses. <b><i>Results:</i></b> A high prevalence (4/11; 36%) of <i>BRAF</i> mutations and lack of <i>cKIT</i> mutations were observed. Amplification of <i>cKIT</i> was found in 18% of cases; cKIT expression was detectable in 18% non-overlapping cases. No correlation between CD117 and <i>cKIT</i> alterations was observed. One (6%) <i>cKIT</i> and two (12%) <i>BRAF</i> mutations were detected in an additional series of 17 acral/mucosal melanomas from the same geographic areas. <b><i>Conclusion:</i></b> Mutations of <i>cKIT</i> are infrequent in sinonasal melanoma in Southern Italy.