RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection

Griffiths, Samantha; Portman, Neil; Taylor, Philip R.; Gordon, Siamon; Ginger, Michael L.; Gull, Keith

Links

ORCID
Crossref | PDF
[www.ncbi.nlm.nih.gov] | PDF
[europepmc.org] | PDF
[www.researchgate.net] | PDF
[www.ncbi.nlm.nih.gov] | PDF
[www.ncbi.nlm.nih.gov] | PDF

Tools

Export citation

Search in Google Scholar

RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection

Journal article published in 2007 by Samantha Griffiths, Neil Portman

, Philip R. Taylor, Siamon Gordon, Michael L. Ginger, Keith Gull

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.