Dissemin is shutting down on January 1st, 2025

Published in

Elsevier, Seminars in Immunology, 2(18), p. 128-135, 2006

DOI: 10.1016/j.smim.2006.01.005

Links

Tools

Export citation

Search in Google Scholar

CD4(+)CD25(+) regulatory T lymphocytes in bone marrow transplantation

Journal article published in 2006 by Olivier Joffre ORCID, Joost P. M. van Meerwijk
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection.