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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 4(60), p. 2519-2523, 2016

DOI: 10.1128/aac.03053-15

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Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases

Journal article published in 2016 by Hong Du, Liang Chen ORCID, Kalyan D. Chavda, Ruchi Pandey, Haifang Zhang, Xiaofang Xie, Yi-Wei Tang ORCID, Barry N. Kreiswirth
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

ABSTRACT Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The bla NDM-1 -harboring plasmids carry IncA/C 2 and IncR replicons, showing a mosaic plasmid structure, and the bla NDM-1 is harbored on a novel class I integron-like element. bla KPC-3 is located on a Tn 3 -Δ bla TEM-1 - bla KPC-3 -ΔTn 1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.