Published in
Springer (part of Springer Nature), Endocrine, 2(51), p. 333-341
DOI: 10.1007/s12020-015-0673-z
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Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins
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Sandro Giannini ,
Maurizio Gallieni,
Marianna Noale,
Giovanni Tripepi,
Maurizio Rossini,
Piergiorgio Messa,
Paolo Rigotti,
Tecla Pati,
Francesco Barbisoni,
Antonio Piccoli,
Andrea Aghi,
Marianna Alessi,
Luciana Bonfante,
Fabrizio Fabris
and other authors.
Full text: Unavailable
Abstract
Matrix Gla protein (MGP) and bone Gla protein (BGP) are two vitamin K-dependent proteins (VKDPs) involved in the regulation of vascular calcification (VC). We carried out a secondary analysis of the VIKI study to evaluate associations between drug consumption and VKDP levels in 387 hemodialyzed patients. The VIKI study assessed the prevalence of vitamin K deficiency in hemodialysis patients. We evaluated drug consumption, determined BGP and MGP levels, and verified the presence of any vertebral fractures (VF) and VC by spine radiographs. Total BGP levels were twice as high with calcimimetics versus no calcimimetics (290 vs. 158.5 mcg/L, p