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American Society of Hematology, Blood, 2(125), p. 273-283, 2015

DOI: 10.1182/blood-2014-05-576470

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Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Journal article published in 2014 by Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms ORCID, Nurul A. Yakob, Jason W. H. Wong ORCID, Kathy Knezevic, John E. Pimanda, Richard B. Lock
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points The glucocorticoid receptor coordinately regulates the antiapoptotic BCL2 and proapoptotic BIM genes in pediatric ALL cells in vivo. GR binding at a novel intronic region is associated with BIM transcription and dexamethasone sensitivity in pediatric ALL cells in vivo.