Published in
Public Library of Science, PLoS ONE, 9(6), p. e25508, 2011
DOI: 10.1371/journal.pone.0025508
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Kv7 Channels Can Function without Constitutive Calmodulin Tethering
,
Alessandro Alaimo ,
Ainhoa Etxeberría,
Juncal Fernández-Orth,
Teresa Zamalloa,
Meritxell Roura-Ferrer,
Patricia Villace,
Pilar Areso,
Oscar Casis ,
Alvaro Villarroel,
Álvaro Villarroel Muñoz
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Abstract
9 p. ; M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding cause Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited human epilepsy. On the basis that Kv7.2 mutants deficient in calmodulin binding are not functional, calmodulin has been defined as an auxiliary subunit of Kv7 channels. However, we have identified a presumably phosphomimetic mutation S511D that permits calmodulin-independent function. Thus, our data reveal that constitutive tethering of calmodulin is not required for Kv7 channel function.