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BioMed Central, Genome Biology, 1(9), p. 201

DOI: 10.1186/gb-2008-9-1-201

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Anchoring the genome

Journal article published in 2008 by Diego Ottaviani, Elliott Lever, Petros Takousis, Denise Sheer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.