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Impact Journals, Oncotarget, 12(6), p. 9679-9685, 2015

DOI: 10.18632/oncotarget.3919

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Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas

Journal article published in 2015 by Núbia Braga Pereira, Ana Carolina de Melo do Carmo, A. C. De Melo do Carmo, Marina Gonçalves Diniz, Ricardo Santiago Gomez, Dawidson Assis Gomes ORCID, Carolina Cavalieri Gomes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Ameloblastoma is a locally invasive neoplasm often associated with morbidity and facial deformities, showing increased Epidermal Growth Factor Receptor (EGFR) expression. Inhibition of EGFR was suggested as a treatment option for a subset of ameloblastomas. However, there are resistance mechanisms that impair anti-EGFR therapies. One important resistance mechanism for EGFR-inhibition is the EGFR nuclear localization, which activates genes responsible for its mitogenic effects, such as Cyclin D1.