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Nature Research, Nature Genetics, 8(48), p. 856-866

DOI: 10.1038/ng.3598

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Journal article published in 2015 by Padhraig Gormley, Arn Mjm J. M. van den Maagdenberg, P. Gormley, Bendik S. (Bendik) Winsvold, Tune H. (Tune) Pers, Mikko Muona ORCID, T. Kurth, George McMahon, Bendik S. Winsvold, Lannie Ligthart, Gisela M. Terwindt, U. (Unda) Todt, Priit Palta ORCID, Caroline Ran ORCID, Anine H. (Anine) Stam and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Data provided by SHERPA/RoMEO

Abstract

Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we performed the largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We identified 44 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P