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Ultrasound evidence of early fetal growth restriction after maternal malaria infection.
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At Papageorghiou,
Supan Thiptharakun,
Suporn Kiricharoen,
Sl Dwell,
Jacher Wiladphaingern,
Mupawjay Pimanpanarak,
Sh Kennedy,
François Nosten,
Rose Mcgready
Abstract
BACKGROUND: Intermittent preventive treatment (IPT), the main strategy to prevent malaria and reduce anaemia and low birthweight, focuses on the second half of pregnancy. However, intrauterine growth restriction may occur earlier in pregnancy. The aim of this study was to measure the effects of malaria in the first half of pregnancy by comparing the fetal biparietal diameter (BPD) of infected and uninfected women whose pregnancies had been accurately dated by crown rump length (CRL) before 14 weeks of gestation. METHODOLOGY/PRINCIPAL FINDINGS: In 3,779 women living on the Thai-Myanmar border who delivered a normal singleton live born baby between 2001-10 and who had gestational age estimated by CRL measurement