Published in

Taylor and Francis Group, Transcription, 5(2), p. 207-210

DOI: 10.4161/trns.2.5.16813

Links

Tools

Export citation

Search in Google Scholar

Effects of theMDM2promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk

Journal article published in 2011 by Stian Knappskog, Per E. Lønning ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylogeny of this gene.