Links
- ORCID
- ORCID
- ORCID
- Crossref | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.manchester.ac.uk]
- [arthritis-research.com] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
,
Yorkshire Early Arthritis Year Yorkshire_Early_Arthritis_(YEAR)_Consortium,
Biologics in Ra Control (BIRAC) Consortium Yorkshire Early Arthritis (YEAR) Consortium,
Anne Hinks,
John Bowes,
Edward Flynn,
Paul Martin ,
Anthony G. Wilson,
Ann W. Morgan,
Paul Emery,
Sophia Steer,
Lynne J. Hocking,
David M. Reid,
Pille Harrison,
Paul Wordsworth
and other authors.
Abstract
Abstract Introduction Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now well established that some of these loci are shared between diseases with similar aetiology. For example, a number of autoimmune diseases have been associated with variants in the PTPN22, TNFAIP3 and CTLA4 genes. Here we have attempted to define overlapping genetic variants between rheumatoid arthritis (RA), type 1 diabetes (T1D) and coeliac disease (CeD). Methods We selected eight SNPs previously identified as being associated with CeD and six T1D-associated SNPs for validation in a sample of 3,962 RA patients and 3,531 controls. Genotyping was performed using the Sequenom MassArray platform and comparison of genotype and allele frequencies between cases and controls was undertaken. A trend test P -value