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Oxford University Press, Social Cognitive and Affective Neuroscience, 3(1), p. 175-182, 2006

DOI: 10.1093/scan/nsl035

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Model syndromes for investigating social cognitive and affective neuroscience: a comparison of autism and Williams syndrome

Journal article published in 2006 by Helen Tager-Flusberg, Daniela Plesa Skwerer, Robert M. Joseph ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Autism and Williams syndrome are genetically based neurodevelopmental disorders that present strikingly different social phenotypes. Autism involves fundamental impairments in social reciprocity and communication, whereas people with Williams syndrome are highly sociable and engaging. This article reviews the behavioral and neuroimaging literature that has explored the neurocognitive mechanisms that underlie these contrasting social phenotypes, focusing on studies of face processing. The article concludes with a discussion of how the social phenotypes of both syndromes may be characterized by impaired connectivity between the amygdala and other critical regions in the ‘social brain’.