Published in
American Society of Hematology, Blood, 11(127), p. 1468-1480, 2016
DOI: 10.1182/blood-2015-08-663146
Links
- American Society of Hematology | PDF
- ORCID
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation
Journal article published in 2016 by
Kellie R. Machlus 
,
Stephen K. Wu,
Deborah J. Stumpo,
Thomas S. Soussou,
David S. Paul,
Robert A. Campbell,
Hermann Kalwa,
Thomas Michel,
Wolfgang Bergmeier,
Andrew S. Weyrich,
Perry J. Blackshear,
John H. Hartwig,
Joseph E. Italiano
,
Stephen K. Wu,
Deborah J. Stumpo,
Thomas S. Soussou,
David S. Paul,
Robert A. Campbell,
Hermann Kalwa,
Thomas Michel,
Wolfgang Bergmeier,
Andrew S. Weyrich,
Perry J. Blackshear,
John H. Hartwig,
Joseph E. Italiano
This paper is made freely available by the publisher.
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Abstract
Key PointsProteomic analyses and polysome profiling of developing MKs identified a striking increase in the levels of a novel protein, MARCKS, during proplatelet formation. MARCKS deletion, inhibition, or phosphorylation inhibits proplatelet formation associated with activation of the actin-binding protein Arp2/3.