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The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Journal article published in 2014 by Laura E. Taggart, Stephen J. McMahon, Fred J. Currell, Kevin M. Prise ORCID, Karl T. Butterworth
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.