The materials used for major sinus lift varies from autogenous or allogenous bone, to animal origin (xenograft) bone or synthetic (alloplastic) materials. A combination of bone substitutes, alloplastic graft with allogenic or xenogenic bone seems to give satisfactory results in terms of new bone formation and the long-term implant success rate. On the other hand, using PRP (Platelet Rich Plasma) mixed with bone substitutes seems to enhance graft vascularization and osseous regeneration, as well as faster healing. The novel sinus lift technique with PRGF (Plasma rich in Growth Factors) has demonstrated significant development of new bone, minimizing any complications in the event of Scheneiderian membrane perforation. The present study compares two clinical cases where major sinus lifts were performed using as regenerative material xenograft bone and porous titanium mixed with PRGF.