Published in
Public Library of Science, PLoS ONE, 6(4), p. e5837, 2009
DOI: 10.1371/journal.pone.0005837
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Endotoxin Induced Chorioamnionitis Prevents Intestinal Development during Gestation in Fetal Sheep
Journal article published in 2009 by
Tim G. A. M. Wolfs 
,
Wim A. Buurman,
Bea Zoer,
Rob M. J. Moonen,
Joep P. M. Derikx ,
Geertje Thuijls,
Eduardo Villamor,
Markus Gantert,
Yves Garnier,
Luc J. I. Zimmermann,
Boris W. Kramer
,
Wim A. Buurman,
Bea Zoer,
Rob M. J. Moonen,
Joep P. M. Derikx ,
Geertje Thuijls,
Eduardo Villamor,
Markus Gantert,
Yves Garnier,
Luc J. I. Zimmermann,
Boris W. Kramer
This paper is made freely available by the publisher.
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Abstract
Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery. Prematurity and prenatal inflammation are associated with compromised postnatal developmental outcomes, of the intestinal immune defence, gut barrier function and the vascular system. We developed a sheep model to study how the antenatal development of the gut was affected by gestation and/or by endotoxin induced chorioamnionitis.