Published in
Public Library of Science, PLoS ONE, 7(7), p. e41139, 2012
DOI: 10.1371/journal.pone.0041139
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Functional Analysis of Two PLA2G2A Variants Associated with Secretory Phospholipase A2-IIA Levels
Journal article published in 2012 by
Holly J. Exeter,
Ferdinand Van't Hooft,
Lasse Folkersen,
Jutta Palmen,
Anders Franco-Cereceda,
Jackie A. Cooper,
Anastasia Z. Kalea 
,
Ferdinand van’t Hooft,
Per Eriksson,
Steve E. Humphries,
Philippa J. Talmud
,
Ferdinand van’t Hooft,
Per Eriksson,
Steve E. Humphries,
Philippa J. Talmud
This paper is made freely available by the publisher.
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Abstract
Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atherosclerosis in observational and animal studies. The protein is encoded by the PLA2G2A gene and the aim of this study was to test the functionality of two PLA2G2A non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously associated with higher and lower sPLA2-IIA levels respectively.