During the long engineering project construction period, involving a combination of human, financial and material, and that different works, every link and each phase is mostly high altitude, open, crossover operation, which hide safety risks and result in high probability of safety accidents, so these characteristics determine the importance of safe and civilized production. Therefore, the influence factors of engineering construction safety are worth studying. In this paper, through extensive reading literature and information, making contrast and analyzing, researching and other methods, finishing the preliminary indicators of construction safety influencing factors, after conducting questionnaire survey, ultimately identified 19 indicators of factors and based on these indicators draw SEM model by AMOS software. The results by AMOS show that the model can effectively describe the relationship between the influence factors of which affecting construction safety, and provide strong evidence for improving the engineering and construction management.