The multi-layer frame-bent industrial factory is a new structure, in the south of China. The anti-seismic performance of longitudinal and transverse directions of the factory is analyzed by SAP2000 software and nonlinear time-history method, in this paper. The S shaped steel dampers are used to the factory. The results show that the application of the S shaped steel dampers reduced shear forces and bending moments of the pillars bottoms and displacements of the floors of the factory; the S shaped steel dampers formed large hysteresis loops, dissipated earthquake energy and reduced the earthquake response of the factory.