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Oxford University Press (OUP), The Journal of Clinical Endocrinology & Metabolism, 4(100), p. 1376-1385

DOI: 10.1210/jc.2014-3631

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Evaluation of 451 Danish Boys With Delayed Puberty: Diagnostic Use of a New Puberty Nomogram and Effects of Oral Testosterone Therapy

Journal article published in 2015 by Jacob Gerner Lawaetz, Casper P. Hagen, Mikkel Grunnet Mieritz, Martin Blomberg Jensen, Martin Blomberg Jensen, Jørgen Holm Petersen, Anders Juul ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

CONTEXT Few data exist on the diagnostic criteria, and on the effects of puberty induction, in boys with constitutional delay in growth and puberty (CDGP). OBJECTIVE To develop puberty nomograms based on Danish boys with normal pubertal development. To evaluate the different diagnostic criteria and the effect of oral testosterone undecanoate (TU) in boys with CDGP. DESIGN A cross-sectional and longitudinal study of Danish boys with normal pubertal development (COPENHAGEN puberty study). A retrospective observational study of 451 boys evaluated for delayed puberty between 1990 and 2013. SETTING Tertiary referral center for pediatric endocrinology. PARTICIPANTS One hundred and sixty-four (36%) boys evaluated for CDGP were excluded due to missing data, reclassification, or associated comorbidities, yielding 287 (64%) eligible for analysis. MAIN OUTCOME MEASURES The number of patients with CDGP classified by the puberty nomogram (genital stage